I use Atomic Email Studio + Amazon SES. I'm sending B2B which makes things a little bit easier. If you're spamming personal emails with pharma offers you'll have a hard time.
I have two SES smtps. One on the Oregon region and one on the N. Virginia region. They give a 50K per day limit but only 14 and 20 emails per second from either server.
Atomic Email Studio has a email verifier app that does a pretty good job. My bounce rate is around 1-3% with this app. It does not remove spam traps which is a concern for me. I get around .1-.2% spam complaints. Overall I do really well with this setup.
If you're sending traffic to a domain, be sure to setup the DKIM and SPF. I purchased all of the TLDs for my brand domain and then redirect those to landing page on my good domain. If you do not do this your main domain will end up on a blacklist.
Here's my setup:
Solid SEO VPS $35 per month - For running scrapebox. I also run GSA Platform Identifier here but that's unrelated.
Scrapebox $67 - For gathering emails
Ahead Host VPS $15 per month - For running email programs. Ahead Host has port 25 open which is necessary for validating emails using Atomic Email Studio.
Atomic Email Studio $229 - For sending, verifying, and managing lists. It also comes with a Yelp scraper and various other email scrape tools.
Amazon SES - For sending emails. $1 for 10k messages. Deliverability is solid.
Instant Proxies $100 per month - I use these for other software but you need proxies to scrape emails.
I handle bounces by exporting my reply-to email inbox and adding them to a blacklist. This is not done automatically. It can be setup to handle bounces automatically but I haven't done it yet.
You're looking at around $450 in initial costs and then around $200 per month (email sending costs + proxies, vps, etc). The ROI is insane and well worth the initial setup cost/hassle.
SendInBlue will let you send cold if you buy a private IP for $140. I say they'll let you only because they banned me and told me I could come back if I bought the private IP. This was when I was just starting out and my bounce rate was around 8% (I didn't know about list cleaning back then).
I have never used Interspire but it looks like it does not include SMTP.
