Safe to spam tier 2 or 3

Dont know if spam is the right word or blasting...=/ Was wondering thoughts on blasting out thousands of tier 2/3 links, say using xranker or GSA. Potential to get penalized by big G?
Or is it ok as long you use some unique domains, proxies, usernames, etc?

you wont get penalized if you send thousands of backlinks to your T2 and T3 backlinks.

Generally proxies and all that is to by pass the security measures for blasting not for penalties themselves.
But the penalty possibility is there. This is why they are called tier2/tier3, the lower the tier, the higher the probability.
Don't get too fond of them