I try to stay relatively sociable. This is one of the main reasons why I maintain a full time job. It allows me to be somewhat strict with my morning regimen and wake time, gets me out of the house for forced reasons twice a week, and allows me to interact with people with similar interests
Besides that, I make it a point to walk my dog a couple times a day, which typically leads to interaction with others in the neighborhood. I hang out with some of my wife's surgeon friends 1-2 times each month as well, and my wife and I have a couple friends from high school who happen to live in the same city as we do by some twist of fate. We have a lot of similar interests, so we hang out with them 1-2 times a month as well.
That, plus getting outside into some fresh air and doing some manual labor every now and then is therapeutic. I mow the (currently dead) lawn, piddle around cleaning the yard, wash and detail the cars, and every now and then sit on the front porch with a book. Once a month I take a full morning to explore the city and take some pictures for one of my online projects. A couple times a month we head to the beach (30 minute drive from home, 15 minute drive from work) to relax, and once a week when I'm in office I try to head that way for lunch time. Sunshine and splashing waves is a great antidepressant.
I have recently been trying to be a stickler about exercise as well. The wife and I did ten miles last weekend in two hours, a nice light jogging pace, but got to interact with several other people, pet some dogs, and enjoy the beautiful Florida weather.
But yeah, I'm surely still depressed here. I still spend most of my day staring at screens. Still deal with the commute twice a week. Still pushing myself too hard with offline and online work, and still feel like there are never enough hours in the day. I'm working on a mindset shift though, and letting go of projects with a minimal enjoyment factor.
Making great money is awesome, but if you don't take time to step back and enjoy life, you are doing things wrong. Don't sacrifice a minute for a dollar.