Yes. Position 1 gets roughly 3 times as many clicks as position 2. The numbers are subjective, but basically you get substantially more by going for number one. A big exception would be where an information site like Wikipedia pops at number one for a keyword that someone is typing in to buy something. For instance, if you did a search for LCD television to make a purchase. If wiki popped at number one and a shopping site popped at number 2, there would not be a big difference. All and all, however, making the effort to bump up to number 1 is always advisable.