What's the difference between manual and bot on Instagram?

Does Follow Liker use the Instagram API or send HTTP requests pretending to be using the app? And what about Igerslike?
 
Has anyone of you guys or know anyone that has gotten banned by following manually?

My lil bro has tons of accounts that he manages manually and up til now, none of them have been banned from my understanding. But he's not really spamming his users with offers though. He's mainly running those accounts for fun.
 
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