Sure, you just have to know what your doing. The problem is people tend to approach things backwards.
You don't want to ask, can I build links with scrapebox.
Scrapebox is an automation tool, and it only automates what you can do manually.
What you want to do is develop a manual process for building great links, then you come and say "This is what I want to do, cause it works, and its great, how can I do this with scrapebox?"
Then you are approaching it from how scrapebox can help you automate what already works.
No offense to above posters, but when someone says "don't do it. I have never done it but I heard its bad" or "you will get a penalty" thats poor advice. What you should do is have test sites and test all sorts of stuff.
Whenever someone tells me not to do something, thats exactly what I do. now don't go testing it on your money site home page, be smart, but do test.
Also in 9+ years of scrapebox I have never heard of someone getting a penalty. If it were really that easy to get a manual penalty and pummel a website from the ranks, don't you think Everyone would just buy scrapebox and use it against their competitors and get all their competitors penalized and then float to the top naturally? Google can't have that, it would destroy their results.
So just remember scrapebox is the swiss army knife of SEO it is not a link building tool. Loads of people think scrapebox is a blog commenting tool, its not. It does do blog comments, but it wasn't designed with that in mind and thats like .0001% of what it can do. You can strap a couch to the top of a car and haul it across town, I mean you can, but thats not what a car is designed for and thats probably not its best use and its not what most people use it for.
Strapping a couch to a car and hauling it is akin to scrapebox building links, yeah it can build links but thats not its best use and not what most people use it for.
Here is a video that will get you going with some theory on how to build top notch links. Your not using scrapebox to directly build the link, but to quantify loads of potential links sources down to the ones that you can then go and chase down manually or hire someone to do cheap etc..