Is web anatomy effect SEO performance? If yes, than how?

Hello everyone,
I want to know that what is the effect of web anatomy in SEO? and what are designing aspect i should keep in mind when i analyze website in aspect of SEO?

Hello, what do you mean by "web anatomy" ? UX design ?

The most important is to A/B test your ad's set, and the better format is the one just above the pagination. (It is also the one with the highest % of accidental clics for adsense)