Here's my solution, and I manage 400 blogs. I found simple tools to make it easy for me to run my stuff.
1. wordpress blogs. They have a wide array of tools, so that they can be fully automated, and with the amount of themes, and settings, you can use dynamic, or static all sorts of good stuff.
2. once you have setup your wordpress blogs, make them auto blogs. You can do this with simple tools, like managewp (currently use to good effect) wp-robot (allows me to drip content as i see fit), and manage wp-robot. managewp will allow you to group your sites into different categories, that way you can work on one niche at a time.
3. once all the blogs are setup, I use manage wp-robot to handle all of my day to day content, and change schedules, and then i work hard at having articles spun. I contract some of the work out on oDesk (you can find people there to write articles really cheap, then spin the bejesus out of them), and put all the stuff in the plr folders.
4. sit back and enjoy. I make about 50 dollars each day per site. With 400 sites, it's easy, and then i find tricks to do in my spare time., such as look at the commets that hit moderation from other spammers, approve them, and then get the info, then delete the commet. FREE PROXIES
That's the only way I have found to stay organized with that many sites. I hope it helps you, it can be a little troublesome to setup though, but once it's done, it's golden