I used to have problems coming up with colors for my webdesign projects, but now I use http://www.colourlovers.com/ to get new ideas and refine my ideas. It's awesome for those of us who are a little challenged with the color wheel.
Something that is easy on the eyes. You do not want to pick two or more colors that just do not go together. Good color combos that work well include light and dark blue, green and gray, red and black, etc. You get the idea.