So far, with my use, this situation has been a good thing. It's usually in situations that bring about a popup, and other blockers just make them disappear without notice. With uBlock Origin, you can select "temporarily" if you clicked it on purpose but are just curious about the contents of the link, or you can click "permanently" if you plan on visiting this site regularly. It's nice to have a choice instead of the blocker just discarding them without notice.
It also gives you the option of just closing the window and forgetting about it. I just like he choice uBlock gives you. I'm not sure how to make the site permablocked. Never really tried.