Actually is not so complicated. Try to split your keywords into categories, so all keywords in a category can be advertised with the same ad and landing page. Make a separated ad group for each category and try using different landing pages that convert for your keywords. Always use 2 ads for 1-2 weeks, keep the winner and make another one to compete with. Try using exact match first, so you won't need to find all the negatives and if the traffic is not enough, start adding phrase match keywords and your known negatives. As soon as you find more negative keywords, add them to your list. Broad match is a waste of money, used by the people who are lazy to start finding all their golden keywords.
Good luck!