I can't feel the effects of alcohol due to a medicine I'm on so I haven't had a drink in over 6 years.
It binds to the delta / kappa opiate receptors along with various GABA & dopamine receptors. So if I drink alcohol, it can't bind to the receptors in my brain and I just sweat it out my skin after 3-4 hours.
Many many years ago, for my brothers bachelor party I drank 5 beers and 3 shots within 2 hours. I was dancing and just waiting for the alcohol to kick in and nothing happened. No buzz. No ego boost. No slurring. No stumbling. No happy feelings. It turned out to be very depressing. So I just sat down and ate food for most the party.