The Best Methods on converting high targeted audience clicks

What methods are the best, for converting very (very) high targeted audience clicks? Lets discuss this please.

I will start:

Shopify (with Dropshipping)
Positive: You can choose the product depending on the audience.
Negative: But the products are limited to the store you use. For every new niche you have to find again a new product.

CPA is always a great way to monetise as long as its audience specific

I vouch for CPA too

Is there a "best" CPA method if the traffic is very high targeted? Hardcore fans.
For example only people which have an old gameboy and play every day.