SENuke is theory is a great tool, in practice it's very mediocre at best and you won't dominate much at all with it.
Every function is buggy in some way or another, for instance Wordpress MU there's 300+ sites and from them it claims it registers to about half then after sending an article out it only posts to about 6 blogs successfully or about 1.5% success rate.
I went and manually made 6 Wordpress MU accounts and posted an article to each by hand in about a tenth the time it took SENuke.
Similar story with the other functions, problems that prevent it from being really effective. After giving it a workout on a few new and old domains and looking at the SERP's the results are less than spectacular.
It does have serious potential, and i hope he polishes it up a lot more but at the moment there's no way i can justify the cost for what it does.