There are many ways to utilize Amazon..
First you need to get approved.. They will review your site. If you don't have anything visually appealing with some decent content you will get denied now.
Find the products in the niche you want to sell. You can either e-mail products or do product reviews, etc. Get creative.
When I ran a successful penny auction that was sold to QuiBids back in 2011, we drop shipped from amazon and paid the $79/year for free 3-day shipping anywhere in the U.S., unlimited products, so that was a big bonus.
It all depends HOW you want to monetize it but you need an affiliate account where you can get your links for each product.
Good luck,
EMP1R3