Sick is another Autosubmitter program.
It's very customizable, and can be scripted to do some complex tasks, but it's problem is that it's a bit slow, and it has trouble with larger lists.
It's still young though, so if it keeps getting improved it will become very good software.
There are a LOT of free packets that come with it, and if you spend some money, you can get some very nice submit lists.
Also, the email confirmer is IMO quite fucking terrible. It works... more often than not. But that's the easiest part of it all.
It's only $20 a month, so it's an absolute bargain. It's the sort of app that's been getting steadily better with time. If SEnuke X ever comes out, Sick will give it a some competition.
If you are lazy and not technical at alll, go senuke. If you're happy to make some custom lists (or just pay staff to make them....), then get sick or xrumer.
It's not in the same league as Xrumer from what I read.... but I haven't used xrumer yet so I don't really know.