You can make anything a No Refund, No Return product if you state it as such in your Terms of Service.
I mean, if you're looking for ideas on products where this policy is a no-brainer, dig around in your bathroom. Tweezers, Toilet Paper, Plungers, Cosmetics, Soap....tons of inspiration to be found there.
But if you just won't want to deal with refunds and returns, just make it clear you don't allow them.