It totally depends on how creatively you use it. If you just blast out a poorly spun article in a classic linkwheel set up and expect quick results on a tough keyword then you are going to be disappointed regardless of whether you use SENuke, any other software, or do it manually. If, on the other hand, you use a really well spun article (or articles) and set up a network of sites focusing on an inner page to your site with an achievable keyword you will have a great long term asset. I frequently go back and post additional articles and add profile information to make them real sites. Then be patient. By promoting inner pages targeting long tail keywords I've been able to improve my SERPs on the more competitive main keyword that I didn't directly target. It's a process that takes at least 2-3 months and involves regularly building various backlinks to the properties. But, once it's built, I have some sites I can use to boost anything in similar niches too.