It depends on too many factors, but keep in mind, python releases a new version every now and then, so it relies on fresh content as well. If your blog for example is new, if you catch the "fresh wave" per se, you'd be able to gain traffic and rankings.
Additionally, as a programmer, you know how you search for answers in Google. Use tools such as "ask the public" to get content ideas related to what people are looking for. But narrow it down, it's a good idea to start from a particular framework or version or path (ie web development - django, flask, etc, data analysis - panda)
Another advice - check out Youtube and what fresh content related to python and/or frameworks there is. See the number of views and engagement, it should give you a good idea what you should go for and what to avoid as it's too competitive. And before you jump into content, use any SEO tool to analyze the top 10 results to see who you're against for a particular keyword.