I need somebody help me please

Hello folks
I hope you all are doing great

I just have a couple of questions, might sound like a silly question for everybody who knows about it, but honestly I don't know. Right now I'm working in a personal project and I need to know the answer of the questions below.

1. It is strictly necessary to install PowerMTA on Interspire or could be installed directly on VestaCP or ISPConfig 3.1 ?

2. Will PowerMTA (SMTP) works with SOCK5 proxies with 25 port blocked ?

Thanks in advance for your help.

lol... Is it really a silly question?

I have absolutely no clue what you are talking about. It looked like a brilliant question prima-facie... (No sarcasm intended)