The answer is no, but that has already been stated.
So lets start with the obvious. Why do you want to make the files uncopyable?
If you don't want someone to see them you could always zip them and put a password on the file. Enough to keep a snooping boss or wife to see whats on a thumb drive, but not enough to keep a hacker from breaking through. That's just a random crappy solution pulled out of when the sun don't shine because of a lack of any real information, but you get the idea. Explain what you want to do it and why and you should get a more detailed answer.