I use a program called Twiping has loads of options such as mass follow/unfollow,lets you know which ones that you have followed have not followed you back,friends that you are not following,lets you make a safe list(never unfollow),ignore list (never follow) and much more
Tweetadder will keep your follow:unfollow ratio in line with what it needs to be, automatically following targets and unfollowing those who don't reciprocate after a day, two or three. Tons of other features as well, though it's a bit buggy at the moment after recent changes.
on tweetbuddy you can unfollow users who aren't following you even if my system didn't follow them in the first place. however twitter has a daily unfollow limit so i cap it
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