Easiest way to do gui for script/program?

I need to make something simple so which of the languages has best solution for gui?
Is it Visual basic? Ive heard Tcl is good

If that is related to a desktop app then VB is fine. If you need something for the website/online app, you can use bootstrap for faster prototyping.

Depends on what language you're comfortable with. VB.net (or C# for that matter) is just fine. Tcl/tk is good, but if using the tk toolkit, then I consider Python's bindings to it (tkinter) to be more simple.
If you don't care about what language you use, then I'd go with VB.net or C# -- as Visual Studio makes it super easy and quick to build a GUI.

My vote for VisualStudio and C#. Python is also fine but doesn't see good designer for making gui