Disagree.
It depends on where the money is coming from.
If the buyer pays you via e-Check (through Paypal), then you cannot send them the item until the e-Check fully clears (takes about six business days, or up to two weeks, maybe more).
If the buyer pays you via Paypal (through their credit card and/or their bank account), then it should say "Instant Payment". At this point, the money is yours. You can safely send the buyer the merchandise.
What is NOT safe is dealing with Paypal... ALWAYS ALWAYS keep your Paypal balance at $0. When you make a sale, get an instant payment, IMMEDIATELY withdraw the money to your bank account. You can withdraw money to bank account an unlimited number of times per day (as opposed to a merchant account, which will charge you $.30 per transfer).
As the poster said above, once the money has hit your bank account, IMMEDIATELY remove the funds from your bank account.
You should have a single bank account associated with each Paypal account. Make CERTAIN that this particular bank account is always empty (I keep a balance of $5 in mine).
edit: I just re-read the OP's question, and just realized that he mentioned that he is a wholesaler. Please note that Paypal has a bad habit of freezing accounts if the amount of money moving through your account is large (say, over $1,000.00). I've heard way too many stories of people receiving $2,500 payments and then suddenly getting their accounts frozen for six months while Paypal "investigates".
I would recommend that you structure payments so that you don't receive more than say, $500 at a time. You may want to set up several Paypal accounts if you deal in large amounts of money. You really have to watch out for Paypal - remember, they are a private company and NOT a bank, which means that they are not overseen by anyone (and can do whatever the hell they want).
Again, I have to mention how dead serious I am about constantly making withdrawals and keeping your Paypal balance at $0. Even if I receive a $10 payment, I'll immediately withdraw it (seriously).