Can you earn more working with Google Ad Manager on content websites?

Hey guys, I am interested in increasing my earnings with adsense and I have seen the Google Ad Manager, is it possible to earn more money with Google Ad Manager than with the advertising codes that Google Adsense gives from its ad panel? Or better to work with companies like Ezoic? My question is that if from Google Ad Manager I can make profit as if I were in Ezoic?