My experience thus far is that Google Adsense is only concerned with how your site appears to potential visitors.
One site I had adsense on was de-indexed as a result of basically looking like a link farm. After I was de-indexed, Adsense eventually had me take down the ads.
Another site I had adsense on was de-indexed as a result of on-site BH SEO techniques, but looked like a completely normal website to a visitor. Adsense never said a word.
So I'm fairly confident that as long as your pages stay clean and appealing to visitors Adsense will let you be.