I regret putting Skype in my profile, for sure. But I now have a second Skype I use that usually doesn't consume any time, rather just all people that can benefit my business in any way. In my post/rant I wrote yesterday I mentioned that I got help from someone with my first site, and how important that was - I got in touch with him on Skype (via a Skype group), so in that sense Skype have been crucial for my business.
I do however agree that Skype makes it easy to get people to ask you a shitload of questions, and they think you are a mentor, which at least I am not (I try to help people most of the time though). This can consume time of your working hours but if you only accept people that will bring something to your business and what can I say "filter" using a primary Skype. Those that you understand will help you proceed in you business in any way can get moved to the second Skype.
That's how I do it.