There isn’t a clear winner between AdSense and Adsterra since results depend heavily on your niche, traffic quality, and audience location. AdSense usually performs better on clean, content-focused sites with strong tier-1 traffic, especially for CPC-based earnings.
Adsterra, on the other hand, can be useful for testing different ad formats or monetizing traffic that doesn’t perform well on AdSense. Many publishers try both and compare RPMs across placements to see which setup brings the best overall return without risking account issues.