Account is disabled

It depends on the reason but once google makes a decision on a suspension, they usually don't change their mind, even if they are in the wrong.
 
If by multiple times you mean, they reject, and offer you the opportunity to rebut, and this happens repeatedly, perhaps you have a chance. I by multiple times you mean they took action against you and you just keep informing them (without them escalating it on their own) that you think they were wrong, you will be ignored.

Repeatedly performing the same action that is not producing a result is not going to help you.
 
it depends why the banned the account, if it was against their TOS you better create a new account, you can continue sending appeals they just ignore them.
 
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