Twitter is very niche-specific. Any niche that thrives on content and discourse will do well on Twitter. That's its selling point; that's why people congregate there.
It depends what kind of automation you're talking about.
Mass following/unfollowing, liking, retweet, etc. are rate-limited by API anyway.
But simple scheduling or conditional actions (not mass actions) can still be accomplished easily.
Having been a porn actor/producer, one of the most important things is to make sure you're putting out great content that targets one niche and one niche only. Think specific, like ballbusting, or pegging, something super-niche that has a small but enthusiastic following that's just hungry for...
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