So, what i'm gathering is that you want to mass mail people and when they "open" this email you've sent it will automatically redirect them to a site?, correct? this would depend on several factors. It would depend on what email client or viewer your target audience is using, and it would depend on whatever method you would use for the redirection. I haven't tested this myself but i would think that the large free email providing companies like hotmail, gmail and yahoo would filter out META refreshes and things of that sort, you would have to think out of the box to get it to refresh to a site if at all possible.
Hope this helps?