Though I haven't found a perfect solution yet, what I use is:
Socialoomph - autofollow those who follow my accounts, and unfollow those who unfollow me, and auto DM reply when someone follows.
I've not tried the pro version yet, but some of the features are sweet. Likely do that in the next couple of weeks at some point.
TweetAdder - until I find another mass follow/unfollow tool which I can use in prospecting for new followers, this one is it. Yeah it's not a lot of fun to connect to proxy A, then open 5 instances of TweetAdder, tell it to unfollow x and follow y numbers of users, then do it again with another proxy and another 5 user accounts. In fact I can see how after you hit a certain number of accounts, it could be unbearable.
Am anxiously awaiting someone to combine socialoomph with tweetadder for an online version which will run completely automagically based on parameters inputted such as:
- profile or tweet keywords (for use in finding new followers)
- # to follow/unfollow each day
- future tweet message files to be uploaded
- spinner to take those tweets and munge them so they would be unique against many accounts
- build in url shortener to reduce urls in scheduled tweets
- etc
Code that, and I'll pay to subscribe!