Currently, we do regular mailings of 500-700 targeted cold prospective clients daily. We use various transactional email services to get our messages out. We typically receive 1-3 spam complaints and 8-15 unsubscribes per mailing. Each email sent has 2-3 obfuscated tracking backlinks to a landing page on our main domain and the reply address uses our main domain as well. I am concerned about the possibility of having our main domain blacklisted. This concern could be unwarranted but I could not find any hard data on how many complaints it takes to get blacklisted. Some questions. What is the likely hood of domain blacklisting based on the figures I provided above? On average how many complaints does it take to get a domain blacklisted? Do the spam services follow links in the emails or only use the sent from and reply to urls? Should I change my reply to email to a different domain? Do I need to/should I host the landing pages on a different domain? Or am I overthinking this?