I won't say that .com will always be the best. Definitely is right now. No argument from me.
However, I'd say that I have started seeing sites of legitimate businesses that use other extensions, specifically .io and such.
digital addresses are like physical addresses. It is an investment in property for the future.
Who knows where the world will take us. Is it a risk? Sure. Is .me better than other extensions? Sure. Is it as good as .com? no, but if you are buying smart, that may not matter.
I'd say if you are looking to diversify and have some cash to do it. Then do it. But don't flip immediately. Wait and sell later.