for 2d you can't beat flash etc. its just good fun, you can get the hang of it and move onto other things after.
for 3d, i'd recommend 3d studio max. It may seem complicated but there are plenty of tutorials. And you'd be suprised at how fucking phenomenal stuff looks rendered with good lighting.
I made a ball of goo, made it glow green and even though it was just still, it looked *SO* good. I can bearly draw, but i was very, very impressed!
Just g00gle some tuts and you'll be on your way - its easy when someone guides you!