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Yes--there are known trap lists floating around... but anything worth using will be a commercial service... and not cheap. Freshaddress and the like.

US CAN-SPAM law does not specifically require opt-in. In fact, it specifically *allows* sending unsolicited commercial email... you just have to explicitly state that the email is an advertisement/commercial in nature. You also have to maintain and adhere to an opt-out (suppression) list... and...

I'd def. take into account the source of the list--did you just stumble across this list or is it from a trusted source? Does it contain only major providers or does it include a lot of random domains?