I think you should be able to run just fine, just that if running on your home computer, that would incur alot of electricity cost, and your pc needs to be running 24/7, which may also require some cooling in that aspect (also $$ for electricity). And you will also need to pay for a good internet connectivity as well (also $$$).
Renting a VPS or a dedicated server, eliminates the need for cooling, etc, electricity, and if you work it out, it can be beneficial and cost saving when renting one as opposed to using your own PC.
My electricity bill increased by 1/3 of the usual in the past due to running 24/7 at home, which I think would be better if hosted on a datacenter instead.